HitPredict

Interactor 1: DCLK1 (O15075)
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Gene: DCLK1

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 740 Hs			1 779
+	Hs
		166574 DCLK1_HUMAN (1-740): 0: 896: 100.00		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Hs
		166557 DCLK1_HUMAN (1-740): 0: 896: 100.00		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		166613 DCLK1_HUMAN (1-740): 0: 896: 100.00		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		682023 AKT1_HUMAN (304-706): 2.75e-132: 402: 24.22		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1039170 KCC2D_HUMAN (385-737): 1.46e-130: 398: 33.05		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1083228 KCC4_HUMAN (386-682): 1.09e-66: 229: 41.14		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1039032 KCC2G_HUMAN (387-647): 2.94e-63: 223: 43.77		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1035399 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		681831 AKT1_HUMAN (304-706): 2.75e-132: 402: 24.22		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Hs
		1167410 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		MPRIP_HUMAN (2-499): 4.76e-44: 173: 16.57
+	Hs
		1022390 KCC2D_HUMAN (385-737): 1.46e-130: 398: 33.05		TIAM1_HUMAN (2-634): 3.43e-44: 174: 12.28
+	Hs
		208297 DCX_HUMAN (6-345): 2.97e-136: 407: 72.13		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		787158 KCC2D_HUMAN (385-737): 1.46e-130: 398: 33.05		RHG25_HUMAN (30-181): 1.01e-21: 102: 23.27
+	Mm
		515244 KCC2A_MOUSE (387-648): 1.01e-64: 224: 42.48		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Rn
		506782 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		CNKR2_RAT (1-468): 2.97e-47: 183: 14.20
+	Rn
		506741 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Mm
		659464 KCC2B_MOUSE (387-647): 3.22e-62: 219: 43.77		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		1334862 KCC2A_HUMAN (387-648): 1.19e-64: 224: 42.48		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		787157 KCC2G_HUMAN (387-647): 2.94e-63: 223: 43.77		RHG25_HUMAN (30-181): 1.01e-21: 102: 23.27