HitPredict

Interactor 1: DCLK1 (O15075)
Serine/threonine-protein kinase DCLK1 (EC 2.7.11.1) (Doublecortin domain-containing protein 3A) (Doublecortin-like and CAM kinase-like 1) (Doublecortin-like kinase 1)
Gene: DCLK1

Interactor 2: NEB1 (Q9ULJ8)
Neurabin-1 (Neurabin-I) (Neural tissue-specific F-actin-binding protein I) (Protein phosphatase 1 regulatory subunit 9A)
Gene: PPP1R9A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0014069 - postsynaptic density
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 740 Hs			1 1098
+	Hs
		1234199 DCLK2_HUMAN (1-725): 0: 801: 66.22		NEB1_HUMAN (1-1098): 6.8e-118: 392: 100.00
+	Hs
		166604 DCLK1_HUMAN (1-740): 0: 896: 100.00		NEB2_HUMAN (1-826): 1.2e-42: 170: 43.65
+	Mm
		1164085 DCLK1_MOUSE (1-740): 0: 883: 96.43		NEB2_MOUSE (1-826): 5.97e-43: 171: 43.42
+	Hs
		166544 DCLK1_HUMAN (1-740): 0: 896: 100.00		AFAD_HUMAN (419-593): 1.96e-23: 110: 30.11
+	Hs
		1234196 DCLK2_HUMAN (1-725): 0: 801: 66.22		NEB2_HUMAN (1-826): 1.2e-42: 170: 43.65
+	Hs
		1021556 M3K3_HUMAN (51-646): 5.47e-139: 424: 18.59		DLG1_HUMAN (225-1097): 2.22e-67: 246: 13.80
+	Mm
		292336 DCX_MOUSE (6-359): 2.77e-137: 410: 69.89		DLG4_MOUSE (376-1098): 3.11e-50: 192: 13.00
+	Mm
		1143346 KCC2D_MOUSE (385-737): 1.46e-130: 398: 33.05		DLG4_MOUSE (376-1098): 3.11e-50: 192: 13.00
+	Mm
		292337 DCX_MOUSE (6-359): 2.77e-137: 410: 69.89		NEB2_MOUSE (1-826): 5.97e-43: 171: 43.42
+	Hs
		208290 DCX_HUMAN (6-345): 2.97e-136: 407: 72.13		NEB2_HUMAN (1-826): 1.2e-42: 170: 43.65
+	Rn
		192513 KCC2D_RAT (385-738): 2.08e-129: 396: 32.96		NEB2_RAT (1-826): 2.53e-45: 178: 43.42
+	Mm
		1161534 KCC2D_MOUSE (385-737): 1.46e-130: 398: 33.05		NEB2_MOUSE (1-826): 5.97e-43: 171: 43.42
+	Mm
		250629 KCC2D_MOUSE (385-737): 1.46e-130: 398: 33.05		LNX1_MOUSE (39-594): 1.44e-29: 128: 12.15
+	Mm
		1143553 KS6A2_MOUSE (388-680): 2.2e-99: 324: 27.24		DLG4_MOUSE (376-1098): 3.11e-50: 192: 13.00
+	Rn
		506744 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		DLG3_RAT (311-1098): 7.81e-70: 253: 13.06
+	Rn
		506740 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		DLG1_RAT (225-1097): 1.18e-66: 244: 13.46
+	Hs
		1047654 KCC1A_HUMAN (378-691): 3.3e-134: 402: 40.82		IL16_HUMAN (152-648): 4.59e-09: 62.9: 16.31
+	Rn
		192511 KCC2G_RAT (387-647): 1.29e-64: 225: 43.77		NEB2_RAT (1-826): 2.53e-45: 178: 43.42
+	Rn
		192510 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		NEB2_RAT (1-826): 2.53e-45: 178: 43.42
+	Rn
		506730 KCC2A_RAT (387-648): 1.01e-64: 224: 42.48		SAM14_RAT (920-1075): 3.39e-35: 141: 47.47