HitPredict

Interactor 1: ERC2 (O15083)
ERC protein 2
Gene: ERC2

Interactor 2: LIPA2 (O75334)
Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2)
Gene: PPFIA2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.573

Property	Details
Experiments	12923177
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042734 - presynaptic membrane GO:0048786 - presynaptic active zone GO:0098978 - glutamatergic synapse
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 957 Hs			1 1257
+	Hs
		166819 ERC2_HUMAN (1-957): 8.46e-83: 289: 100.00		LIPA3_HUMAN (1-1257): 1.49e-110: 377: 55.59
+	Hs
		166833 ERC2_HUMAN (1-957): 8.46e-83: 289: 100.00		LIPA1_HUMAN (1-1257): 6.82e-109: 372: 62.89
+	Hs
		166822 ERC2_HUMAN (1-957): 8.46e-83: 289: 100.00		LIPA4_HUMAN (2-535): 4.35e-25: 115: 62.45
+	Hs
		725097 MYH10_HUMAN (322-957): 9.67e-32: 136: 12.15		MYH11_HUMAN (226-1016): 5.09e-40: 164: 12.24
+	Hs
		724687 MYH10_HUMAN (322-957): 9.67e-32: 136: 12.15		MYH9_HUMAN (1-629): 2.88e-25: 116: 12.71
+	Hs
		528432 MYH13_HUMAN (21-799): 1.33e-30: 132: 11.14		MYH8_HUMAN (2-616): 1.57e-24: 114: 8.92
+	Hs
		724943 MY18A_HUMAN (219-918): 7.67e-28: 124: 15.23		MYH9_HUMAN (1-629): 2.88e-25: 116: 12.71
+	Hs
		725095 MYH10_HUMAN (322-957): 9.67e-32: 136: 12.15		MYH10_HUMAN (3-517): 9.54e-21: 101: 12.41
+	Hs
		1268060 MY18A_HUMAN (219-918): 7.67e-28: 124: 15.23		MY18A_HUMAN (41-596): 1.41e-23: 110: 16.28
+	Hs
		528435 MYH8_HUMAN (11-741): 1.43e-35: 149: 12.30		MYH4_HUMAN (493-1048): 5.04e-15: 82.9: 9.25
+	Hs
		502933 MYH3_HUMAN (18-693): 1.02e-29: 130: 10.44		MYH4_HUMAN (493-1048): 5.04e-15: 82.9: 9.25
+	Hs
		522657 MYH7_HUMAN (15-674): 5.44e-29: 127: 10.60		MYH4_HUMAN (493-1048): 5.04e-15: 82.9: 9.25
+	Hs
		724686 MYH9_HUMAN (21-480): 5.51e-17: 88.6: 10.13		MYH9_HUMAN (1-629): 2.88e-25: 116: 12.71
+	Hs
		1268126 MY18A_HUMAN (219-918): 7.67e-28: 124: 15.23		MRCKB_HUMAN (4-315): 1.39e-11: 71.4: 12.65
+	Mm
		93570 DESP_MOUSE (124-891): 6.94e-25: 114: 14.38		MYH9_MOUSE (546-1039): 1.28e-13: 78.3: 11.47
+	Ce
		218988 O44490_CAEEL (157-779): 3.4e-16: 85.5: 15.88		LIPA_CAEEL (2-466): 8.27e-12: 72.1: 11.56