HitPredict

Interactor 1: ANR28 (O15084)
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK)
Gene: ANKRD28

Interactor 2: MYPT2 (O60237)
Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)
Gene: PPP1R12B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank_2~Ank_2, Ank_2~Ank_4
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1053 Hs			1 982
+	Hs
		225134 ANK2_HUMAN (114-909): 0: 633: 27.86		MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00
+	Hs
		167036 ANR28_HUMAN (7-1053): 0: 844: 100.00		ANR50_HUMAN (42-901): 1.12e-64: 240: 12.85
+	Hs
		166913 ANR28_HUMAN (7-1053): 0: 844: 100.00		ANK2_HUMAN (38-320): 2.2e-60: 228: 21.58
+	Hs
		166849 ANR28_HUMAN (7-1053): 0: 844: 100.00		ANR28_HUMAN (3-309): 3.9e-60: 225: 16.89
+	Hs
		166969 ANR28_HUMAN (7-1053): 0: 844: 100.00		ANR44_HUMAN (58-435): 6.79e-59: 221: 17.83
+	Hs
		166919 ANR28_HUMAN (7-1053): 0: 844: 100.00		ANK3_HUMAN (7-505): 1.1e-57: 220: 14.13
+	Hs
		166971 ANR28_HUMAN (7-1053): 0: 844: 100.00		ANR52_HUMAN (5-343): 1.08e-55: 211: 16.71
+	Hs
		225123 ANK1_HUMAN (295-1050): 1.7e-167: 540: 23.92		MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00
+	Hs
		166869 ANR28_HUMAN (7-1053): 0: 844: 100.00		TNKS1_HUMAN (77-182): 3.24e-09: 63.2: 33.02
+	Hs
		167014 ANR28_HUMAN (7-1053): 0: 844: 100.00		TNKS2_HUMAN (77-173): 9.86e-09: 61.6: 36.08
+	Hs
		883487 ANK2_HUMAN (114-909): 0: 633: 27.86		RIPK4_HUMAN (21-365): 7.55e-66: 239: 21.07
+	Hs
		965154 ANK2_HUMAN (114-909): 0: 633: 27.86		Q9H4D1_HUMAN (21-365): 2.96e-65: 237: 21.07
+	Hs
		862028 ANK2_HUMAN (114-909): 0: 633: 27.86		DAPK1_HUMAN (84-555): 2.93e-45: 179: 16.33
+	Hs
		965160 ANK2_HUMAN (114-909): 0: 633: 27.86		TANC2_HUMAN (13-880): 2.73e-35: 148: 12.43
+	Mm
		103608 ANK2_MOUSE (114-909): 0: 628: 27.74		ANK3_MOUSE (182-376): 6.28e-21: 101: 15.82
+	Mm
		103591 ANK3_MOUSE (411-1052): 1.65e-132: 444: 25.04		ANK3_MOUSE (182-376): 6.28e-21: 101: 15.82