HitPredict

Interactor 1: ARHGB (O15085)
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
Gene: ARHGEF11

Interactor 2: PLXB1 (O43157)
Plexin-B1 (Semaphorin receptor SEP)
Gene: PLXNB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.712

Property	Details
Experiments	12183458, 12123608, 12220504, 12730235, 22404908
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005096 - GTPase activator activity GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1522 Hs			1 2135
+	Mm
		1148466 Q68FM7_MOUSE (1-1522): 0: 879: 81.95		PLXB1_MOUSE (1-2135): 0: 2476: 86.70
+	Hs
		195990 ARHGC_HUMAN (6-1457): 0: 596: 29.71		PLXB1_HUMAN (1-2135): 0: 2543: 100.00
+	Mm
		1208656 ARHGC_MOUSE (6-1457): 0: 606: 31.01		PLXB1_MOUSE (1-2135): 0: 2476: 86.70
+	Hs
		167118 ARHGB_HUMAN (1-1522): 0: 936: 100.00		PLXB3_HUMAN (27-1257): 7.56e-179: 598: 30.07
+	Hs
		165122 ARHGB_HUMAN (1-1522): 0: 936: 100.00		PLXB2_HUMAN (22-976): 1.33e-175: 588: 28.92
+	Mm
		1148467 Q68FM7_MOUSE (1-1522): 0: 879: 81.95		PLXB3_MOUSE (27-1391): 3.68e-180: 602: 28.45
+	Mm
		71306 Q68FM7_MOUSE (1-1522): 0: 879: 81.95		PLXB2_MOUSE (23-1229): 2.66e-168: 567: 25.74
+	Hs
		165264 ARHGC_HUMAN (6-1457): 0: 596: 29.71		PLXB2_HUMAN (22-976): 1.33e-175: 588: 28.92
+	Mm
		101476 FARP1_MOUSE (205-1177): 5.14e-119: 402: 15.19		MET_MOUSE (1027-1524): 2.14e-102: 364: 24.16
+	Mm
		110600 H3BJU7_MOUSE (526-1485): 3.01e-115: 389: 17.16		MET_MOUSE (1027-1524): 2.14e-102: 364: 24.16
+	Hs
		441580 VAV3_HUMAN (553-1281): 6.21e-116: 388: 15.46		MET_HUMAN (28-558): 2.89e-95: 342: 20.73
+	Hs
		441472 VAV2_HUMAN (553-1306): 2.19e-109: 370: 14.78		MET_HUMAN (28-558): 2.89e-95: 342: 20.73
+	Mm
		554983 TRIO_MOUSE (348-1351): 3.57e-79: 292: 12.46		MET_MOUSE (1027-1524): 2.14e-102: 364: 24.16
+	Mm
		57826 KALRN_MOUSE (337-1518): 9.23e-70: 262: 11.92		MET_MOUSE (1027-1524): 2.14e-102: 364: 24.16
+	Mm
		100126 F6U8U1_MOUSE (735-891): 4.24e-13: 74.3: 30.00		MET_MOUSE (1027-1524): 2.14e-102: 364: 24.16
+	Dm
		55338 A1ZAN6_DROME (48-249): 2.14e-46: 186: 30.73		Q0E8S4_DROME (20-524): 2.22e-28: 126: 19.36
+	Dm
		55339 A1ZAN6_DROME (48-249): 2.14e-46: 186: 30.73		SEM1A_DROME (20-524): 2.2e-28: 126: 19.36
+	Dm
		1097383 Q9U7D8_DROME (741-930): 2.82e-14: 80.5: 25.64		SEM1A_DROME (20-524): 2.2e-28: 126: 19.36
+	Dm
		1001987 Q9U7D8_DROME (741-930): 2.82e-14: 80.5: 25.64		Q0KIF1_DROME (481-818): 1.29e-19: 98.7: 15.36