HitPredict

Interactor 1: ARHGB (O15085)
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
Gene: ARHGEF11

Interactor 2: PAK4 (O96013)
Serine/threonine-protein kinase PAK 4 (EC 2.7.11.1) (p21-activated kinase 4) (PAK-4)
Gene: PAK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	32203420, 26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001558 - regulation of cell growth GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1522 Hs			1 591
+	Hs
		167086 ARHGB_HUMAN (1-1522): 0: 936: 100.00		KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39
+	Hs
		167116 ARHGB_HUMAN (1-1522): 0: 936: 100.00		PAK5_HUMAN (1-323): 8.93e-40: 156: 27.68
+	Hs
		331058 ARHG2_HUMAN (512-1485): 3e-114: 387: 18.46		PAK4_HUMAN (1-591): 0: 586: 100.00
+	Hs
		850719 ARHGC_HUMAN (6-1457): 0: 596: 29.71		KS6A3_HUMAN (265-591): 5.2e-113: 355: 24.27
+	Hs
		1073489 ARHGC_HUMAN (6-1457): 0: 596: 29.71		KS6A1_HUMAN (275-583): 1.39e-109: 346: 24.39
+	Hs
		1273290 ARHG2_HUMAN (512-1485): 3e-114: 387: 18.46		PAK5_HUMAN (1-323): 8.93e-40: 156: 27.68
+	Hs
		1217590 ITSN2_HUMAN (713-1100): 1.19e-86: 315: 23.56		M4K3_HUMAN (316-574): 1.61e-52: 195: 40.00
+	Hs
		1026200 ARHG2_HUMAN (512-1485): 3e-114: 387: 18.46		PAK1_HUMAN (3-210): 7.55e-29: 122: 19.62
+	Hs
		277606 ITSN1_HUMAN (107-1100): 3.88e-101: 360: 14.02		PAK3_HUMAN (3-210): 5.28e-25: 111: 19.56