HitPredict

Interactor 1: ARHGB (O15085)
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
Gene: ARHGEF11

Interactor 2: RHOC (P08134)
Rho-related GTP-binding protein RhoC (Rho cDNA clone 9) (h9)
Gene: RHOC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~Ras, PH_16~Ras, Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1522 Hs			1 193
+	Hs
		167078 ARHGB_HUMAN (1-1522): 0: 936: 100.00		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		167081 ARHGB_HUMAN (1-1522): 0: 936: 100.00		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		167077 ARHGB_HUMAN (1-1522): 0: 936: 100.00		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		167079 ARHGB_HUMAN (1-1522): 0: 936: 100.00		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		900985 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		436545 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00
+	Hs
		894523 ARHGC_HUMAN (6-1457): 0: 596: 29.71		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		916029 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		892637 ARHGC_HUMAN (6-1457): 0: 596: 29.71		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		901085 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		925760 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		436587 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOC_HUMAN (1-193): 5.13e-80: 238: 100.00
+	Hs
		951489 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92
+	Hs
		894619 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		CDC42_HUMAN (1-193): 7.44e-78: 232: 51.30
+	Hs
		545718 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RAC2_HUMAN (1-193): 2.27e-77: 231: 54.12
+	Hs
		916095 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RHOB_HUMAN (1-191): 3.6e-77: 230: 84.82
+	Hs
		901037 VAV3_HUMAN (553-1281): 6.21e-116: 388: 15.46		RHOA_HUMAN (1-193): 2.98e-81: 241: 91.71
+	Hs
		925718 VAV3_HUMAN (553-1281): 6.21e-116: 388: 15.46		RAC1_HUMAN (1-193): 7.23e-81: 240: 57.22
+	Hs
		892698 FARP1_HUMAN (205-1177): 4.41e-119: 402: 14.95		RAC3_HUMAN (1-179): 9.72e-75: 224: 57.54
+	Hs
		951449 VAV3_HUMAN (553-1281): 6.21e-116: 388: 15.46		RHOG_HUMAN (1-193): 3.54e-78: 233: 54.92