HitPredict

Interactor 1: SMAD7 (O15105)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Gene: SMAD7

Interactor 2: RN111 (Q6ZNA4)
E3 ubiquitin-protein ligase Arkadia (EC 2.3.2.27) (RING finger protein 111) (hRNF111) (RING-type E3 ubiquitin transferase Arkadia)
Gene: RNF111

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	0.60	0.680

Property	Details
Experiments	27292644, 14657019, 35484112, 23530056
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032991 - protein-containing complex and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 426 Hs			1 994
+	Mm
		192493 SMAD7_MOUSE (1-426): 2.83e-174: 495: 98.12		RN111_MOUSE (1-994): 0: 862: 90.54
+	Rn
		88973 SMAD7_RAT (1-426): 3.22e-174: 495: 97.89		D4A9T1_RAT (1-994): 0: 848: 89.64
+	Hs
		206966 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		RN111_HUMAN (1-994): 0: 902: 100.00
+	Hs
		950208 SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72		RN111_HUMAN (1-994): 0: 902: 100.00
+	Hs
		1078571 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		RN111_HUMAN (1-994): 0: 902: 100.00
+	Mm
		1143950 SMAD2_MOUSE (82-424): 1.68e-138: 406: 24.53		RN111_MOUSE (1-994): 0: 862: 90.54
+	Hs
		167372 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26
+	Hs
		206967 SMAD6_HUMAN (1-425): 5.75e-147: 428: 43.56		ARK2C_HUMAN (651-994): 2.56e-59: 208: 41.26
+	Hs
		1078590 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		KMT2C_HUMAN (336-939): 5.75e-15: 82.4: 12.93