HitPredict

Interactor 1: SMAD7 (O15105)
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
Gene: SMAD7

Interactor 2: HDAC5 (Q9UQL6)
Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)
Gene: HDAC5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	15831498, 15831516
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0046872 - metal ion binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 426 Hs			1 1122
+	Hs
		950330 SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72		HDAC5_HUMAN (1-1122): 0: 727: 100.00
+	Gg
		948943 SMAD3_CHICK (81-424): 3.61e-145: 421: 26.58		HDAC4_CHICK (1-1122): 0: 676: 56.41
+	Hs
		880680 SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		880740 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		HDAC4_HUMAN (1-1101): 0: 653: 54.96
+	Hs
		167357 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		167378 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		167309 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		HDAC3_HUMAN (679-1119): 5.97e-144: 441: 21.57
+	Hs
		1038667 SMAD5_HUMAN (79-424): 5.54e-146: 425: 24.08		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		950168 SMAD3_HUMAN (81-424): 2.22e-146: 424: 26.72		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1038410 SMAD1_HUMAN (79-424): 2.02e-145: 423: 24.26		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1038409 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1078604 SMAD2_HUMAN (82-424): 5.2e-138: 404: 24.53		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		167404 SMAD7_HUMAN (1-426): 1.58e-170: 486: 100.00		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97
+	Mm
		140253 SMAD4_MOUSE (54-259): 5.35e-42: 157: 22.38		HDAC1_MOUSE (673-1103): 1.61e-153: 468: 21.16
+	Hs
		1035421 SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75		HDAC1_HUMAN (673-1103): 1.54e-153: 468: 21.16
+	Hs
		1035524 SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75		HDAC2_HUMAN (680-1113): 1.34e-153: 468: 21.68
+	Hs
		1035616 SMAD4_HUMAN (54-259): 3.55e-41: 155: 22.75		HDAC6_HUMAN (599-1061): 7.06e-106: 362: 31.97