HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0044877 - protein-containing complex binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 465
+	Hs
		227863 MARK2_HUMAN (12-724): 1.19e-142: 439: 15.92		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Mm
		291482 IKKB_MOUSE (1-743): 0: 584: 49.13		HOIL1_MOUSE (12-448): 2.29e-67: 225: 17.50
+	Hs
		226028 ROCK2_HUMAN (10-739): 5.13e-122: 399: 16.40		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228986 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Mm
		1141262 IKKA_MOUSE (1-745): 0: 573: 95.44		HOIL1_MOUSE (12-448): 2.29e-67: 225: 17.50
+	Hs
		226557 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		228960 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		167451 IKKA_HUMAN (1-745): 0: 588: 100.00		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		158377 IKKB_HUMAN (1-743): 0: 583: 50.87		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		226457 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		226534 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00
+	Hs
		475222 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		UBB_HUMAN (1-234): 1.14e-59: 197: 17.92
+	Mm
		841459 TBK1_MOUSE (15-726): 8e-127: 396: 18.68		RN19A_MOUSE (236-452): 2.59e-30: 126: 21.62
+	Hs
		476524 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	Hs
		475745 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		UBC_HUMAN (1-77): 1.15e-29: 124: 32.47
+	At
		1091642 CDPKB_ARATH (5-439): 6.96e-123: 378: 19.27		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091646 MPK4_ARATH (18-353): 3.08e-122: 372: 22.32		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	At
		1091641 KIN10_ARATH (14-304): 4.79e-112: 350: 25.17		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17
+	Hs
		270450 KS6A5_HUMAN (1-314): 1.41e-86: 292: 22.05		RN19A_HUMAN (236-452): 6.6e-31: 128: 21.62
+	At
		955189 KIN11_ARATH (14-302): 7.86e-90: 292: 25.69		UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17