HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: TNFA (P01375)
Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
Gene: TNF

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

The method score is based on:

Property	Details
Experiments	27307491, 27545878, 20005846, 19287455
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003009 - skeletal muscle contraction GO:0006954 - inflammatory response GO:0009410 - response to xenobiotic stimulus GO:0009615 - response to virus GO:0033209 - tumor necrosis factor-mediated signaling pathway and 4 others more... GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	745
Hs

1	233

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024