HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 14743216
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042803 - protein homodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 724
+	Hs
		158374 IKKB_HUMAN (1-743): 0: 583: 50.87		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		167446 IKKA_HUMAN (1-745): 0: 588: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		158371 IKKB_HUMAN (1-743): 0: 583: 50.87		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431932 Q59GT1_HUMAN (1-702): 0: 550: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438465 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432196 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		438593 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438164 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		432334 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431843 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437908 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438585 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431549 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		432326 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		270363 KS6A5_HUMAN (1-314): 1.41e-86: 292: 22.05		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		538107 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Zm
		35496 A0A1D6QH07_MAIZE (4-445): 5.19e-122: 374: 18.32		A0A1D6LMW9_MAIZE (5-693): 0: 852: 46.66
+	Hs
		1123982 Q59GT1_HUMAN (1-702): 0: 550: 100.00		Q6PK50_HUMAN (1-350): 0: 618: 99.71
+	Hs
		1123962 Q59GL9_HUMAN (67-512): 1.14e-131: 400: 56.98		Q6PK50_HUMAN (1-350): 0: 618: 99.71
+	Hs
		1050223 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		Q6PK50_HUMAN (1-350): 0: 618: 99.71