HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: IKBA (P25963)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
Gene: NFKBIA

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 26186194, 28514442, 32912968, 33961781, 9751059, 10094049, 18519641, 19959994, 11940602, 24618592, 15310755, 16219905, 12624112, 29958295, 9252186, 9346485, 16493072, 35918322, 11313968, 12054687 and 46 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, tandem affinity purification, in-gel kinase assay, anti tag coimmunoprecipitation, protein kinase assay
Interaction Type physical association, direct interaction, phosphorylation reaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ank_2~Pkinase, Ank_5~Pkinase
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007249 - canonical NF-kappaB signal transduction
GO:0032088 - negative regulation of NF-kappaB transcription factor activity
and 5 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 745
Hs

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Last updated: 15 Jul 2024