HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: IKBB (Q15653)
NF-kappa-B inhibitor beta (NF-kappa-BIB) (I-kappa-B-beta) (IkB-B) (IkB-beta) (IkappaBbeta) (Thyroid receptor-interacting protein 9) (TR-interacting protein 9) (TRIP-9)
Gene: NFKBIB

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	33961781, 9346485, 11485410, 9689078, 14743216
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Ank~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0006954 - inflammatory response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 356
+	Mm
		291461 IKKB_MOUSE (1-743): 0: 584: 49.13		IKBB_MOUSE (1-355): 1.52e-80: 251: 83.52
+	Hs
		158478 IKKB_HUMAN (1-743): 0: 583: 50.87		IKBB_HUMAN (1-356): 9.91e-80: 249: 100.00
+	Hs
		167475 IKKA_HUMAN (1-745): 0: 588: 100.00		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Bt
		1259266 IKKB_BOVIN (1-742): 0: 588: 49.60		Q8WNW7_BOVIN (14-335): 8.63e-77: 240: 30.82
+	Hs
		167522 IKKA_HUMAN (1-745): 0: 588: 100.00		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Hs
		158400 IKKB_HUMAN (1-743): 0: 583: 50.87		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Mm
		1141248 IKKA_MOUSE (1-745): 0: 573: 95.44		IKBB_MOUSE (1-355): 1.52e-80: 251: 83.52
+	Mm
		291486 IKKB_MOUSE (1-743): 0: 584: 49.13		IKBA_MOUSE (7-335): 8.92e-77: 240: 31.07
+	Hs
		158446 IKKB_HUMAN (1-743): 0: 583: 50.87		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Bt
		1259267 IKKA_BOVIN (1-745): 0: 581: 96.51		Q8WNW7_BOVIN (14-335): 8.63e-77: 240: 30.82
+	Hs
		121549 IKKA_HUMAN (1-745): 0: 588: 100.00		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Hs
		121546 IKKB_HUMAN (1-743): 0: 583: 50.87		IKBE_HUMAN (25-333): 1.22e-60: 204: 31.72
+	Hs
		167471 IKKA_HUMAN (1-745): 0: 588: 100.00		BCL3_HUMAN (49-151): 2.25e-12: 69.8: 28.16
+	Hs
		167469 IKKA_HUMAN (1-745): 0: 588: 100.00		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Hs
		158394 IKKB_HUMAN (1-743): 0: 583: 50.87		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57
+	Hs
		639818 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		IKBA_HUMAN (14-335): 5.39e-78: 243: 30.21
+	Hs
		961442 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		NFKB2_HUMAN (35-347): 1.91e-71: 240: 31.15
+	Hs
		862065 MARK2_HUMAN (12-724): 1.19e-142: 439: 15.92		DAPK1_HUMAN (1-260): 1.41e-48: 177: 22.22
+	Hs
		167031 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		ANR28_HUMAN (6-181): 6.32e-24: 105: 22.60
+	Hs
		587739 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		NFKB1_HUMAN (28-140): 2.07e-10: 64.4: 29.57