Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK
Interactor 2: M3K21 (Q5TCX8)
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)
Gene: MAP3K21
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.55 | 1.00 | 0.747 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 26859459 |
| Identification Methods | anti bait coimmunoprecipitation, protein kinase assay, anti tag coimmunoprecipitation |
| Interaction Type | physical association, phosphorylation reaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | PK_Tyr_Ser-Thr~Pkinase |
| Common GO terms | GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0006468 - protein phosphorylation GO:0042803 - protein homodimerization activity |
| Homologous interactions | 12 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
