HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: SHC4 (Q6S5L8)
SHC-transforming protein 4 (Rai-like protein) (RaLP) (SHC-transforming protein D) (hShcD) (Src homology 2 domain-containing-transforming protein C4) (SH2 domain protein C4)
Gene: SHC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 630
+	Hs
		99738 IKKA_HUMAN (1-745): 0: 588: 100.00		F5H5M1_HUMAN (287-630): 9.1e-90: 283: 100.00
+	Hs
		167457 IKKA_HUMAN (1-745): 0: 588: 100.00		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		158385 IKKB_HUMAN (1-743): 0: 583: 50.87		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		331416 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		APBA3_HUMAN (20-452): 1.32e-52: 191: 14.41
+	Mm
		936588 ROCK2_MOUSE (10-739): 1.3e-122: 400: 16.67		ANS1B_MOUSE (64-385): 9.92e-48: 183: 16.82
+	Hs
		523189 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		433470 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		YES_HUMAN (367-628): 2.22e-43: 165: 16.12
+	Hs
		209164 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		NCK2_HUMAN (398-618): 7.15e-41: 154: 16.07
+	Hs
		557816 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		NCK1_HUMAN (425-615): 6.64e-40: 151: 17.35
+	Hs
		523184 KS6B2_HUMAN (15-419): 1.39e-115: 359: 21.24		SRC_HUMAN (385-628): 4.11e-44: 167: 14.77
+	Hs
		655451 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Hs
		655461 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Mm
		933113 KAPCB_MOUSE (2-316): 5.88e-89: 284: 27.47		ANS1B_MOUSE (64-385): 9.92e-48: 183: 16.82
+	Hs
		924564 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		GRB2_HUMAN (520-616): 5.11e-14: 73.4: 30.48
+	Hs
		970698 KCC1A_HUMAN (15-298): 9.69e-89: 285: 26.06		APBA1_HUMAN (129-460): 4.49e-41: 161: 17.85
+	Hs
		568554 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		P85A_HUMAN (506-622): 3.58e-20: 97.1: 24.19
+	Dm
		1213395 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		Q9VGK8_DROME (416-597): 5.63e-14: 77.2: 21.51
+	Hs
		970746 MARK1_HUMAN (13-221): 9.17e-25: 112: 34.11		APBA1_HUMAN (129-460): 4.49e-41: 161: 17.85