HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: MYH14 (Q7Z406)
Myosin-14 (Myosin heavy chain 14) (Myosin heavy chain, non-muscle IIc) (Non-muscle myosin heavy chain IIc) (NMHC II-C)
Gene: MYH14

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32707033, 14743216
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003009 - skeletal muscle contraction GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 1995
+	Hs
		1189798 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH14_HUMAN (1-1995): 0: 1079: 100.00
+	Hs
		167486 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		167488 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH11_HUMAN (752-1430): 1.46e-29: 131: 16.26
+	Hs
		167487 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		158414 IKKB_HUMAN (1-743): 0: 583: 50.87		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		725010 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		724823 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		625176 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		528359 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH6_HUMAN (947-1995): 6.66e-65: 247: 17.38
+	Hs
		728513 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH11_HUMAN (752-1430): 1.46e-29: 131: 16.26
+	Hs
		568567 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62
+	Hs
		610795 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH2_HUMAN (1150-1995): 8.08e-54: 211: 15.50
+	Hs
		522538 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH1_HUMAN (1150-1995): 2.05e-53: 209: 15.50
+	Hs
		528401 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH8_HUMAN (1564-1995): 1.48e-23: 111: 14.58
+	Hs
		725242 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		725161 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		625177 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		610802 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MYH4_HUMAN (1589-1995): 4.96e-22: 106: 14.25
+	Hs
		568568 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		MYH10_HUMAN (1656-1994): 1.36e-12: 75.9: 12.39
+	Hs
		724967 MARK4_HUMAN (13-224): 1.59e-24: 111: 34.56		MYH9_HUMAN (1010-1995): 3.22e-56: 219: 16.62