HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: MAVS (Q7Z434)
Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
Gene: MAVS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	18550535, 16177806
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0032727 - positive regulation of interferon-alpha production GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045087 - innate immune response GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 540
+	Hs
		158497 IKKB_HUMAN (1-743): 0: 583: 50.87		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		158388 IKKB_HUMAN (1-743): 0: 583: 50.87		MUC1_HUMAN (160-534): 7.43e-16: 83.3: 10.90
+	Mm
		799601 IKKA_MOUSE (1-745): 0: 573: 95.44		CBP_MOUSE (82-395): 1.15e-11: 69.8: 14.24
+	Hs
		1190121 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		1050231 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		568717 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00
+	Hs
		610744 KAPCB_HUMAN (5-316): 3.65e-89: 285: 26.96		MAVS_HUMAN (1-540): 1.73e-73: 245: 100.00