HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: RB6I2 (Q8IUD2)
ELKS/Rab6-interacting/CAST family member 1 (ERC-1) (Rab6-interacting protein 2)
Gene: ERC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	15218148
Identification Methods	biochemical, affinity chromatography technology
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007252 - I-kappaB phosphorylation GO:0008385 - IkappaB kinase complex GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 1116
+	Hs
		158505 IKKB_HUMAN (1-743): 0: 583: 50.87		RB6I2_HUMAN (1-1116): 2.23e-82: 293: 100.00
+	Hs
		167488 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH11_HUMAN (2-719): 7.51e-34: 144: 10.30
+	Hs
		167486 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92
+	Hs
		167487 IKKA_HUMAN (1-745): 0: 588: 100.00		MYH10_HUMAN (664-1113): 2.61e-18: 93.3: 12.09
+	Hs
		158414 IKKB_HUMAN (1-743): 0: 583: 50.87		MYH10_HUMAN (664-1113): 2.61e-18: 93.3: 12.09
+	Mm
		93554 IKKA_MOUSE (1-745): 0: 573: 95.44		DESP_MOUSE (262-1099): 8.8e-15: 82: 12.52
+	Hs
		728513 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH11_HUMAN (2-719): 7.51e-34: 144: 10.30
+	Hs
		725010 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92
+	Hs
		724823 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92
+	Hs
		149212 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		CTRO_HUMAN (156-792): 2.47e-18: 93.5: 12.63
+	Hs
		625176 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH9_HUMAN (2-736): 1.6e-33: 142: 9.92
+	Hs
		725242 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		MYH10_HUMAN (664-1113): 2.61e-18: 93.3: 12.09
+	Rn
		92843 ROCK2_RAT (10-739): 4.73e-121: 396: 16.40		CTRO_RAT (152-731): 4.63e-17: 89.3: 14.72
+	Hs
		528401 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH8_HUMAN (3-541): 4.07e-23: 109: 10.26
+	Hs
		725161 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		MYH10_HUMAN (664-1113): 2.61e-18: 93.3: 12.09
+	Hs
		625177 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		MYH10_HUMAN (664-1113): 2.61e-18: 93.3: 12.09
+	Bt
		1100183 ROCK2_BOVIN (10-739): 1.91e-121: 397: 16.14		ROCK2_BOVIN (193-847): 1.07e-09: 65.1: 20.39
+	Hs
		551702 IKKE_HUMAN (15-728): 1.47e-123: 387: 19.52		DESP_HUMAN (457-1104): 2.2e-09: 64.3: 13.22
+	Rn
		222476 MRCKA_RAT (7-735): 9.13e-113: 377: 18.65		MRCKB_RAT (362-928): 3.7e-10: 66.6: 22.66
+	Hs
		551610 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		DESP_HUMAN (457-1104): 2.2e-09: 64.3: 13.22