HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: TNIP2 (Q8NFZ5)
TNFAIP3-interacting protein 2 (A20-binding inhibitor of NF-kappa-B activation 2) (ABIN-2) (Fetal liver LKB1-interacting protein)
Gene: TNIP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	30561431, 21784860
Identification Methods	affinity chromatography technology, enzymatic study, virotrap
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006954 - inflammatory response GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 429
+	Hs
		158510 IKKB_HUMAN (1-743): 0: 583: 50.87		TNIP2_HUMAN (1-429): 0: 648: 100.00
+	Hs
		1245220 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TNIP2_HUMAN (1-429): 0: 648: 100.00