HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: EGLN3 (Q9H6Z9)
Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)
Gene: EGLN3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	23732909
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 239
+	Hs
		158546 IKKB_HUMAN (1-743): 0: 583: 50.87		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		1305592 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		1327876 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		1332730 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		625601 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		EGLN3_HUMAN (1-239): 5.66e-162: 449: 100.00
+	Hs
		1326661 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		EGLN1_HUMAN (2-225): 3.05e-143: 409: 64.29
+	Hs
		625561 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		EGLN2_HUMAN (12-226): 6.89e-132: 379: 61.86