HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: TPX2 (Q9ULW0)
Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)
Gene: TPX2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	17939994
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Aurora-A_bind~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 747
+	Hs
		158565 IKKB_HUMAN (1-743): 0: 583: 50.87		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Mm
		57488 IKKA_MOUSE (1-745): 0: 573: 95.44		TPX2_MOUSE (1-746): 1.65e-150: 458: 77.67
+	Hs
		1183147 MARK2_HUMAN (12-724): 1.19e-142: 439: 15.92		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Hs
		1355353 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Hs
		1349679 MARK1_HUMAN (13-221): 9.17e-25: 112: 34.11		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Hs
		647981 MARK3_HUMAN (13-221): 1.13e-24: 112: 35.05		TPX2_HUMAN (1-747): 2.4e-154: 468: 100.00
+	Hs
		625528 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		TITIN_HUMAN (55-725): 1e-09: 64.5: 11.90