HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: FBW1A (Q9Y297)
F-box/WD repeat-containing protein 1A (E3RSIkappaB) (Epididymis tissue protein Li 2a) (F-box and WD repeats protein beta-TrCP) (pIkappaBalpha-E3 receptor subunit)
Gene: BTRC

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12504025
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0038061 - non-canonical NF-kappaB signal transduction GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 605
+	Hs
		158572 IKKB_HUMAN (1-743): 0: 583: 50.87		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Mm
		291459 IKKB_MOUSE (1-743): 0: 584: 49.13		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		1305605 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Mm
		192187 M3K5_MOUSE (14-745): 7.07e-128: 414: 17.73		FBW1A_MOUSE (1-605): 0: 547: 98.68
+	Hs
		1355365 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1305598 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Mm
		192191 M3K5_MOUSE (14-745): 7.07e-128: 414: 17.73		FBW1B_MOUSE (96-605): 2.25e-143: 428: 85.69
+	Hs
		568836 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		FBW1A_HUMAN (1-605): 0: 551: 100.00
+	Hs
		1327880 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		568826 KAPCA_HUMAN (3-316): 7.79e-90: 287: 27.41		FBW1B_HUMAN (96-605): 1.89e-143: 428: 85.69
+	Hs
		1281380 SIK2_HUMAN (7-731): 2.17e-125: 398: 15.52		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		1281455 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		625543 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		FBXW7_HUMAN (76-527): 7.38e-83: 276: 23.71
+	Hs
		625202 CDK2_HUMAN (12-312): 1.65e-123: 372: 23.30		LIS1_HUMAN (174-494): 8.99e-74: 243: 21.37
+	Hs
		1163028 M3K5_HUMAN (14-745): 1.84e-130: 421: 18.34		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Hs
		1163046 TBK1_HUMAN (15-726): 2.03e-127: 397: 18.82		TRAF7_HUMAN (416-589): 7.75e-29: 123: 27.12
+	Dm
		1213409 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		NLE_DROME (218-531): 8.76e-63: 216: 20.22
+	Dm
		218248 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		O44382_DROME (466-605): 2.38e-30: 127: 29.37
+	Dm
		1213390 AKT1_DROME (3-371): 1.03e-88: 293: 22.58		Q9VDE3_DROME (466-605): 2.66e-30: 126: 29.37