HitPredict

Interactor 1: IKKA (O15111)
Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK-1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
Gene: CHUK

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 1.00 0.997

The method score is based on:

Property Details
Experiments 21455180, 26500060, 28249776, 30404796, 11057907, 35271311, 35952808, 32707033, 36736316, 36916940, 9751060, 19815509, 21903422, 16497931, 11485410, 17000764, 12486103, 22547678, 18949366, 25304104 and 50 others

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Identification Methods affinity chromatography technology, biochemical, enzymatic study, pull down, unspecified method, tandem affinity purification, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, protein array, virotrap
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains IKKbetaNEMObind~NEMO
Common GO terms GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006954 - inflammatory response
GO:0006955 - immune response
and 10 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Hs

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Last updated: 15 Jul 2024