HitPredict

Interactor 1: LSM1 (O15116)
U6 snRNA-associated Sm-like protein LSm1 (Cancer-associated Sm-like) (Small nuclear ribonuclear CaSm)
Gene: LSM1

Interactor 2: LSM6 (P62312)
U6 snRNA-associated Sm-like protein LSm6
Gene: LSM6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.81	1.00	0.902

Property	Details
Experiments	29395067, 33961781, 28514442, 15231747
Identification Methods	proximity labelling technology, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	LSM~LSM
Common GO terms	GO:0000932 - P-body GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol and 1 others more... GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 133 Hs			1 80
+	Hs
		167728 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		LSM4_HUMAN (8-80): 5.81e-33: 112: 27.03
+	Hs
		167678 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57
+	Hs
		167726 LSM1_HUMAN (1-133): 3.57e-53: 165: 100.00		LSM2_HUMAN (10-80): 3.6e-20: 78.4: 27.03
+	At
		1228011 LSM1B_ARATH (7-118): 1.52e-37: 125: 48.21		LSM6A_ARATH (1-80): 1.4e-31: 107: 80.00
+	Dm
		1369698 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9VKW8_DROME (8-80): 4.87e-33: 112: 27.03
+	Hs
		321444 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM4_HUMAN (8-80): 5.81e-33: 112: 27.03
+	Hs
		321388 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM6_HUMAN (1-80): 3.99e-33: 110: 100.00
+	Dm
		1097032 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		RUXF_DROME (2-74): 1.97e-30: 104: 43.84
+	Hs
		321386 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57
+	Dm
		1376063 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9W2P5_DROME (4-80): 4.69e-29: 100: 85.71
+	Dm
		1374114 Q9W2K2_DROME (1-124): 3.53e-39: 130: 63.71		Q9VTW6_DROME (10-80): 5.28e-20: 78: 27.03
+	At
		1340905 LSM7_ARATH (4-88): 3.76e-28: 100: 28.89		LSM6A_ARATH (1-80): 1.4e-31: 107: 80.00
+	Hs
		911992 LSM7_HUMAN (8-89): 4.34e-27: 98.5: 29.89		RUXF_HUMAN (5-74): 6.03e-31: 105: 48.57
+	Sc
		746307 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM2_YEAST (10-80): 8.12e-19: 74.9: 25.68
+	Sc
		810539 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM6_YEAST (9-77): 1.95e-18: 73.8: 46.58
+	Dm
		1374112 Q9W087_DROME (8-97): 1.7e-31: 109: 26.37		Q9VTW6_DROME (10-80): 5.28e-20: 78: 27.03
+	Hs
		321440 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		LSM2_HUMAN (10-80): 3.6e-20: 78.4: 27.03
+	Hs
		321390 LSM8_HUMAN (7-95): 2.25e-31: 108: 33.33		SMD3_HUMAN (8-77): 5.73e-19: 76.1: 21.43
+	Sc
		767790 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM4_YEAST (8-80): 1.63e-11: 58.4: 21.43
+	Sc
		810530 LSM1_YEAST (4-123): 5.07e-34: 118: 40.98		LSM3_YEAST (6-78): 2.79e-09: 50.3: 28.75