HitPredict

Interactor 1: ARC1B (O15143)
Actin-related protein 2/3 complex subunit 1B (Arp2/3 complex 41 kDa subunit) (p41-ARC)
Gene: ARPC1B

Interactor 2: ARP5L (Q9BPX5)
Actin-related protein 2/3 complex subunit 5-like protein (Arp2/3 complex 16 kDa subunit 2) (ARC16-2)
Gene: ARPC5L

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.930

Property	Details
Experiments	26186194, 28514442, 24981860, 33961781, 26655834
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	P16-Arc~WD40
Common GO terms	GO:0005885 - Arp2/3 protein complex GO:0005925 - focal adhesion GO:0034314 - Arp2/3 complex-mediated actin nucleation GO:0051015 - actin filament binding GO:0070062 - extracellular exosome
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 372 Hs			1 153
+	Dm
		333000 O97182_DROME (9-371): 4.38e-102: 308: 50.00		Q9VQD8_DROME (1-149): 3.62e-62: 189: 48.67
+	Hs
		1270205 ARC1A_HUMAN (1-371): 6.17e-84: 261: 67.83		ARP5L_HUMAN (1-153): 1.54e-71: 213: 100.00
+	Hs
		181342 ARC1A_HUMAN (1-371): 6.17e-84: 261: 67.83		ARPC5_HUMAN (1-153): 1.65e-66: 200: 68.18
+	Hs
		168683 ARC1B_HUMAN (9-372): 1.2e-79: 250: 100.00		ARPC5_HUMAN (1-153): 1.65e-66: 200: 68.18
+	Sc
		748538 ARPC1_YEAST (96-366): 5.97e-09: 59.3: 9.82		ARPC5_YEAST (6-153): 4.52e-51: 161: 29.03