HitPredict

Interactor 1: ARPC2 (O15144)
Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
Gene: ARPC2

Interactor 2: ARP3B (Q9P1U1)
Actin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)
Gene: ACTR3B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.950

Property	Details
Experiments	28514442, 17353931, 29568061, 33961781, 24981860, 35271311
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~P34-Arc
Common GO terms	GO:0051015 - actin filament binding GO:0070062 - extracellular exosome
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 300 Hs			1 418
+	Hs
		168909 ARPC2_HUMAN (1-300): 2.42e-171: 478: 100.00		ARP3_HUMAN (1-418): 0: 571: 90.67
+	Dm
		689664 ARPC2_DROME (1-298): 2.26e-161: 452: 75.50		ARP3_DROME (1-418): 0: 557: 79.67
+	Hs
		168907 ARPC2_HUMAN (1-300): 2.42e-171: 478: 100.00		ACTB_HUMAN (1-414): 0: 528: 35.42
+	Hs
		168914 ARPC2_HUMAN (1-300): 2.42e-171: 478: 100.00		ACTG_HUMAN (1-414): 0: 528: 35.18
+	Dm
		862569 ARPC2_DROME (1-298): 2.26e-161: 452: 75.50		ACT3_DROME (3-414): 0: 520: 35.11
+	Sc
		811954 ARPC2_YEAST (1-300): 6.35e-110: 323: 35.57		ARP3_YEAST (6-417): 2.6e-173: 493: 57.46