HitPredict

Interactor 1: ARPC3 (O15145)
Actin-related protein 2/3 complex subunit 3 (Arp2/3 complex 21 kDa subunit) (p21-ARC)
Gene: ARPC3

Interactor 2: ARPC5 (O15511)
Actin-related protein 2/3 complex subunit 5 (Arp2/3 complex 16 kDa subunit) (p16-ARC)
Gene: ARPC5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

The method score is based on:

Property	Details
Experiments	28514442, 33961781, 26186194, 24981860, 35271311, 23148219, 26655834
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005200 - structural constituent of cytoskeleton GO:0005634 - nucleus GO:0005829 - cytosol GO:0005885 - Arp2/3 protein complex GO:0005925 - focal adhesion and 7 others more... GO:0015629 - actin cytoskeleton GO:0030027 - lamellipodium GO:0030833 - regulation of actin filament polymerization GO:0034314 - Arp2/3 complex-mediated actin nucleation GO:0035861 - site of double-strand break GO:0051015 - actin filament binding GO:0070062 - extracellular exosome
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	178
Hs

1	151

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024