HitPredict

Interactor 1: MUSK (O15146)
Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
Gene: MUSK

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.50	0.558

Property	Details
Experiments	35384245, 25036637
Identification Methods	affinity chromatography technology, proximity labelling technology, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 869 Hs			1 378
+	Hs
		427002 CSF1R_HUMAN (28-862): 3.54e-155: 481: 20.63		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		674444 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1018328 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		434207 RET_HUMAN (493-869): 1.79e-118: 388: 33.85		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1079717 Q15850_HUMAN (550-869): 4.71e-124: 382: 37.89		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		601520 FGFR2_HUMAN (21-330): 7.1e-72: 255: 20.05		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		411399 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		435654 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		537743 INSRR_HUMAN (569-852): 5.57e-67: 245: 42.61		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		508026 FGFR1_HUMAN (1-330): 4.65e-67: 241: 17.79		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		607988 FGFR4_HUMAN (10-301): 5.06e-66: 238: 18.26		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082788 DDR2_HUMAN (557-856): 6.1e-65: 235: 40.94		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		994639 DDR1_HUMAN (568-856): 2.57e-64: 234: 40.45		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Dm
		448241 INSR_DROME (539-864): 7.85e-66: 243: 38.34		CDC37_DROME (1-351): 1.28e-126: 371: 52.54
+	Hs
		987248 TYRO3_HUMAN (17-224): 1.62e-31: 134: 23.15		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1082785 NTRK2_HUMAN (121-298): 2.06e-21: 102: 23.94		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		968308 ROR1_HUMAN (12-127): 2.79e-21: 102: 25.83		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		968388 ROR2_HUMAN (30-121): 4.69e-20: 97.8: 27.66		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1081495 NTRK3_HUMAN (28-203): 2.23e-19: 95.5: 25.26		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		729287 VGFR3_HUMAN (14-360): 3.3e-18: 92.5: 15.51		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00