HitPredict

Interactor 1: MUSK (O15146)
Muscle, skeletal receptor tyrosine-protein kinase (EC 2.7.10.1) (Muscle-specific tyrosine-protein kinase receptor) (MuSK) (Muscle-specific kinase receptor)
Gene: MUSK

Interactor 2: Q6PK50 (Q6PK50)
Heat shock protein HSP 90-beta
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25036637
Identification Methods	luminescence based mammalian interactome mapping
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 869 Hs			1 351
+	Hs
		169160 MUSK_HUMAN (1-869): 0: 794: 100.00		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		169159 MUSK_HUMAN (1-869): 0: 794: 100.00		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		426977 CSF1R_HUMAN (28-862): 3.54e-155: 481: 20.63		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		426974 CSF1R_HUMAN (28-862): 3.54e-155: 481: 20.63		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		437923 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431568 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		438114 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431788 MERTK_HUMAN (111-865): 1.2e-148: 465: 22.37		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		499223 KIT_HUMAN (19-865): 5.06e-153: 476: 18.88		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		431435 RET_HUMAN (493-869): 1.79e-118: 388: 33.85		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		1079718 Q15850_HUMAN (550-869): 4.71e-124: 382: 37.89		Q6PK50_HUMAN (1-345): 2.04e-180: 505: 100.00
+	Hs
		538120 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		674450 UFO_HUMAN (7-868): 2.19e-152: 472: 20.51		H90B3_HUMAN (1-345): 2.38e-137: 404: 79.13
+	Hs
		435497 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431438 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Hs
		437855 INSRR_HUMAN (569-852): 5.57e-67: 245: 42.61		HS90B_HUMAN (1-345): 1.2e-175: 506: 100.00
+	Hs
		431488 INSRR_HUMAN (569-852): 5.57e-67: 245: 42.61		HS90A_HUMAN (1-350): 1.31e-173: 501: 84.92
+	Rn
		544887 INSR_RAT (569-857): 2.08e-69: 253: 42.22		ENPL_RAT (2-351): 8.26e-142: 422: 42.25
+	Hs
		411287 INSR_HUMAN (569-857): 8.73e-70: 254: 42.22		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54
+	Hs
		435523 IGF1R_HUMAN (569-852): 1.93e-69: 253: 42.96		ENPL_HUMAN (2-351): 6.06e-139: 415: 42.54