HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: P73 (O15350)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: TP73

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.732

Property	Details
Experiments	30603043, 28514442, 29523541, 33961781, 11223036, 21088494
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008285 - negative regulation of cell population proliferation GO:0051726 - regulation of cell cycle
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 636
+	Hs
		175856 MDM2_HUMAN (2-488): 0: 554: 31.56		P73_HUMAN (1-636): 0: 1034: 100.00
+	Hs
		169308 MDM4_HUMAN (1-490): 0: 692: 100.00		P63_HUMAN (1-629): 0: 870: 54.39
+	Mm
		620862 MDM2_MOUSE (2-488): 0: 532: 29.78		P73_MOUSE (6-636): 0: 992: 88.99
+	Hs
		962970 MDM2_HUMAN (2-488): 0: 554: 31.56		P63_HUMAN (1-629): 0: 870: 54.39
+	Hs
		169227 MDM4_HUMAN (1-490): 0: 692: 100.00		P53_HUMAN (110-379): 2.03e-136: 406: 50.00
+	Mm
		193155 MDM4_MOUSE (1-490): 0: 678: 83.91		P53_MOUSE (97-411): 6.53e-142: 419: 44.00
+	Hs
		386540 MDM2_HUMAN (2-488): 0: 554: 31.56		P53_HUMAN (110-379): 2.03e-136: 406: 50.00
+	Mm
		356823 MDM2_MOUSE (2-488): 0: 532: 29.78		P53_MOUSE (97-411): 6.53e-142: 419: 44.00
+	Rn
		88787 D3ZVH5_RAT (2-488): 0: 518: 28.43		P53_RAT (9-404): 2.63e-138: 410: 39.55
+	Hs
		111246 J3KN53_HUMAN (2-488): 0: 519: 28.80		P53_HUMAN (110-379): 2.03e-136: 406: 50.00