HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	16511560, 36931259, 16511572
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0051726 - regulation of cell cycle
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 248
+	Hs
		169269 MDM4_HUMAN (1-490): 0: 692: 100.00		1433E_HUMAN (2-246): 4.41e-146: 410: 60.41
+	Hs
		169273 MDM4_HUMAN (1-490): 0: 692: 100.00		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		169241 MDM4_HUMAN (1-490): 0: 692: 100.00		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Hs
		683969 MDM2_HUMAN (2-488): 0: 554: 31.56		1433S_HUMAN (1-248): 3.48e-158: 440: 100.00
+	Hs
		169244 MDM4_HUMAN (1-490): 0: 692: 100.00		1433B_HUMAN (1-239): 3.41e-100: 293: 68.62
+	Hs
		169266 MDM4_HUMAN (1-490): 0: 692: 100.00		1433G_HUMAN (1-242): 1.86e-98: 289: 65.16
+	Hs
		169280 MDM4_HUMAN (1-490): 0: 692: 100.00		1433F_HUMAN (2-242): 2.78e-96: 283: 64.20
+	Mm
		193158 MDM4_MOUSE (1-490): 0: 678: 83.91		1433G_MOUSE (1-242): 1.86e-98: 289: 65.16
+	Hs
		926930 MDM2_HUMAN (2-488): 0: 554: 31.56		1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37
+	Hs
		646805 MDM2_HUMAN (2-488): 0: 554: 31.56		1433T_HUMAN (1-238): 9.98e-108: 312: 71.85
+	Mm
		620839 MDM2_MOUSE (2-488): 0: 532: 29.78		1433T_MOUSE (1-238): 7.63e-107: 310: 71.43