HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	28514442, 18356162, 16511560
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0043066 - negative regulation of apoptotic process
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 245
+	Hs
		169269 MDM4_HUMAN (1-490): 0: 692: 100.00		1433E_HUMAN (2-241): 9.9e-144: 403: 68.18
+	Hs
		169241 MDM4_HUMAN (1-490): 0: 692: 100.00		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Hs
		169244 MDM4_HUMAN (1-490): 0: 692: 100.00		1433B_HUMAN (1-242): 9.01e-140: 393: 87.60
+	Hs
		169266 MDM4_HUMAN (1-490): 0: 692: 100.00		1433G_HUMAN (1-240): 2.37e-108: 314: 74.59
+	Hs
		169280 MDM4_HUMAN (1-490): 0: 692: 100.00		1433F_HUMAN (2-240): 1.26e-107: 312: 74.49
+	Hs
		169245 MDM4_HUMAN (1-490): 0: 692: 100.00		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97
+	Mm
		193158 MDM4_MOUSE (1-490): 0: 678: 83.91		1433G_MOUSE (1-240): 2.37e-108: 314: 74.59
+	Hs
		926930 MDM2_HUMAN (2-488): 0: 554: 31.56		1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00
+	Hs
		646805 MDM2_HUMAN (2-488): 0: 554: 31.56		1433T_HUMAN (1-245): 2.6e-140: 395: 79.59
+	Mm
		620839 MDM2_MOUSE (2-488): 0: 532: 29.78		1433T_MOUSE (1-245): 8.98e-140: 393: 79.18
+	Hs
		683969 MDM2_HUMAN (2-488): 0: 554: 31.56		1433S_HUMAN (1-237): 8.27e-104: 302: 71.97