Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4
Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.99 | 1.00 | 0.998 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 24813712, 25384516, 20705607, 26001071, 25512388, 25809483, 25105592, 25659040, 25825738, 26359458, 27215386, 27621617, 27617579, 25961923, 27777309, 29057323, 29295817, 29262653, 29524278, 31024344 and 51 others
more... |
| Identification Methods | pull down, affinity chromatography technology, unspecified method, enzymatic study, fluorescent resonance energy transfer, two hybrid, x-ray crystallography, biochemical, protein complementation assay, coimmunoprecipitation and 3 others
more... |
| Interaction Type | direct interaction, physical association, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | zf-C3HC4_3~zf-C3HC4_3 |
| Common GO terms | GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003181 - atrioventricular valve morphogenesis GO:0003203 - endocardial cushion morphogenesis GO:0003281 - ventricular septum development GO:0003283 - atrial septum development and 12 others more... |
| Homologous interactions | 5 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
