HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: PPARD (Q03181)
Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
Gene: PPARD

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008270 - zinc ion binding GO:0045892 - negative regulation of DNA-templated transcription and 1 others more... GO:0071456 - cellular response to hypoxia
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 441
+	Hs
		962739 MDM2_HUMAN (2-488): 0: 554: 31.56		PPARD_HUMAN (1-441): 5.15e-125: 371: 100.00
+	Hs
		740502 MDM2_HUMAN (2-488): 0: 554: 31.56		PPARG_HUMAN (13-441): 3.64e-114: 346: 57.28
+	Hs
		369419 MDM2_HUMAN (2-488): 0: 554: 31.56		ESR1_HUMAN (1-437): 1.92e-102: 318: 19.82
+	Hs
		509934 MDM2_HUMAN (2-488): 0: 554: 31.56		VDR_HUMAN (57-439): 7.97e-102: 311: 24.16
+	Hs
		782520 MDM2_HUMAN (2-488): 0: 554: 31.56		HNF4A_HUMAN (54-437): 8.86e-100: 307: 21.30
+	Hs
		487946 MDM2_HUMAN (2-488): 0: 554: 31.56		RARA_HUMAN (20-439): 9.06e-98: 302: 25.94
+	Rn
		88792 D3ZVH5_RAT (2-488): 0: 518: 28.43		PPARA_RAT (1-441): 3.04e-106: 324: 59.42
+	Hs
		265863 MDM2_HUMAN (2-488): 0: 554: 31.56		NR1I2_HUMAN (74-437): 2.75e-30: 123: 25.98