HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: UBP7 (Q93009)
Ubiquitin carboxyl-terminal hydrolase 7 (EC 3.4.19.12) (Deubiquitinating enzyme 7) (Herpesvirus-associated ubiquitin-specific protease) (Ubiquitin thioesterase 7) (Ubiquitin-specific-processing protease 7)
Gene: USP7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.700

Property	Details
Experiments	20713061, 31519875, 15916963, 18566590
Identification Methods	x-ray crystallography, pull down, unspecified method, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association, direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0050821 - protein stabilization
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 1102
+	Mm
		193159 MDM4_MOUSE (1-490): 0: 678: 83.91		UBP7_MOUSE (1-1102): 0: 1159: 99.00
+	Hs
		962904 MDM2_HUMAN (2-488): 0: 554: 31.56		UBP7_HUMAN (1-1102): 0: 1165: 100.00
+	Mm
		620848 MDM2_MOUSE (2-488): 0: 532: 29.78		UBP7_MOUSE (1-1102): 0: 1159: 99.00
+	Hs
		169314 MDM4_HUMAN (1-490): 0: 692: 100.00		UBP22_HUMAN (45-521): 2.51e-107: 347: 16.43
+	Hs
		962847 MDM2_HUMAN (2-488): 0: 554: 31.56		UBP48_HUMAN (206-572): 1.45e-102: 349: 26.90
+	Hs
		962979 MDM2_HUMAN (2-488): 0: 554: 31.56		UBP42_HUMAN (162-683): 1.67e-95: 334: 18.44
+	Hs
		962832 MDM2_HUMAN (2-488): 0: 554: 31.56		UBP51_HUMAN (61-525): 3.06e-95: 321: 16.58
+	Hs
		259276 MDM2_HUMAN (2-488): 0: 554: 31.56		UBP12_HUMAN (189-522): 1.4e-89: 294: 25.55