HitPredict

Interactor 1: MDM4 (O15151)
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)
Gene: MDM4

Interactor 2: HIPK2 (Q9H2X6)
Homeodomain-interacting protein kinase 2 (hHIPk2) (EC 2.7.11.1)
Gene: HIPK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25961923
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030330 - DNA damage response, signal transduction by p53 class mediator GO:0051726 - regulation of cell cycle and 1 others more... GO:0071456 - cellular response to hypoxia
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 490 Hs			1 1198
+	Hs
		962969 MDM2_HUMAN (2-488): 0: 554: 31.56		HIPK2_HUMAN (1-1198): 0: 885: 100.00
+	Mm
		292436 MDM2_MOUSE (2-488): 0: 532: 29.78		HIPK1_MOUSE (8-1198): 0: 661: 60.45
+	Hs
		169230 MDM4_HUMAN (1-490): 0: 692: 100.00		CDK1_HUMAN (196-530): 5.99e-119: 372: 24.27
+	Hs
		324790 MDM2_HUMAN (2-488): 0: 554: 31.56		M4K4_HUMAN (178-1175): 7.82e-125: 416: 12.87
+	Hs
		681795 MDM2_HUMAN (2-488): 0: 554: 31.56		AKT1_HUMAN (30-516): 1.3e-121: 386: 16.27
+	Hs
		962893 MDM2_HUMAN (2-488): 0: 554: 31.56		DYRK2_HUMAN (160-606): 2.42e-117: 379: 31.04
+	Mm
		620830 MDM2_MOUSE (2-488): 0: 532: 29.78		AKT1_MOUSE (30-516): 8.46e-122: 386: 16.47
+	Hs
		962771 MDM2_HUMAN (2-488): 0: 554: 31.56		DYR1A_HUMAN (197-530): 6.34e-56: 210: 39.30