HitPredict

Interactor 1: RPAC1 (O15160)
DNA-directed RNA polymerases I and III subunit RPAC1 (DNA-directed RNA polymerase I subunit C) (RNA polymerases I and III subunit AC1) (AC40) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (RPA40) (RPA39) (RPC40)
Gene: POLR1C

Interactor 2: RPB1B (Q9GZM3)
DNA-directed RNA polymerase II subunit RPB11-b1 (RNA polymerase II subunit B11-b1) (RPB11b1) (DNA-directed RNA polymerase II subunit J2)
Gene: POLR2J2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	32296183
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	RNA_pol_L~RNA_pol_L_2
Common GO terms	GO:0003677 - DNA binding GO:0046983 - protein dimerization activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 346 Hs			1 115
+	Hs
		169946 RPAC1_HUMAN (1-346): 6.24e-179: 501: 100.00		RPB1C_HUMAN (1-115): 1.6e-52: 162: 99.13
+	Hs
		169818 RPAC1_HUMAN (1-346): 6.24e-179: 501: 100.00		RPB11_HUMAN (1-108): 5.83e-46: 145: 94.50
+	Hs
		169778 RPAC1_HUMAN (1-346): 6.24e-179: 501: 100.00		RPAC2_HUMAN (29-108): 3.17e-34: 116: 32.50
+	Sp
		293857 RPAC1_SCHPO (6-346): 6.06e-150: 427: 49.71		RPAC2_SCHPO (24-108): 4.9e-33: 113: 36.47
+	Sc
		429651 RPAC1_YEAST (10-338): 1.98e-143: 410: 44.88		RPAC2_YEAST (14-108): 4.25e-34: 116: 31.58
+	Dm
		1368240 Q9VMX3_DROME (30-343): 7.43e-139: 399: 53.97		RPAC2_DROME (31-108): 1.17e-27: 99.3: 30.77
+	Hs
		583571 RPB3_HUMAN (45-346): 4.01e-105: 311: 26.38		RPB1B_HUMAN (1-115): 1.03e-51: 160: 100.00
+	At
		1104914 NRPB3_ARATH (41-346): 6.05e-109: 322: 29.15		NRPBB_ARATH (1-108): 2.13e-45: 144: 47.71
+	At
		1104915 RPD3B_ARATH (41-346): 1.4e-106: 316: 29.47		NRPBB_ARATH (1-108): 2.13e-45: 144: 47.71
+	Hs
		583438 RPB3_HUMAN (45-346): 4.01e-105: 311: 26.38		RPB11_HUMAN (1-108): 5.83e-46: 145: 94.50
+	Mm
		956874 RPB3_MOUSE (45-346): 3.26e-105: 311: 26.71		Q3TYI2_MOUSE (1-108): 3.75e-45: 143: 93.58
+	Dm
		333012 O97183_DROME (45-346): 3.36e-105: 311: 22.95		RPB11_DROME (1-108): 3.28e-44: 141: 75.23
+	Sc
		558050 RPB3_YEAST (46-346): 5.64e-100: 299: 25.74		RPB11_YEAST (1-107): 9.17e-42: 135: 50.93
+	Sc
		557923 RPB3_YEAST (46-346): 5.64e-100: 299: 25.74		RPAC2_YEAST (14-108): 4.25e-34: 116: 31.58
+	Sp
		741615 RPB3_SCHPO (50-344): 8.21e-89: 270: 24.50		RPB11_SCHPO (1-104): 5.16e-38: 125: 47.12
+	Ss
		955989 RPO3_SACS2 (50-343): 4.62e-79: 244: 28.09		RPO11_SACS2 (18-105): 1.37e-25: 93.5: 31.82
+	Mj
		1123053 RPO3_METJA (51-266): 1.23e-52: 174: 26.94		RPO11_METJA (18-107): 8.29e-19: 76.6: 23.47