HitPredict

Interactor 1: TIF1A (O15164)
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
Gene: TRIM24

Interactor 2: CBX1 (P83916)
Chromobox protein homolog 1 (HP1Hsbeta) (Heterochromatin protein 1 homolog beta) (HP1 beta) (Heterochromatin protein p25) (M31) (Modifier 1 protein) (p25beta)
Gene: CBX1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Chromo~PHD
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1050 Hs			1 185
+	Hs
		170353 TIF1A_HUMAN (1-1050): 0: 590: 100.00		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Mm
		1145016 TIF1A_MOUSE (1-1050): 0: 587: 92.23		Q9DCC5_MOUSE (1-177): 2.11e-63: 195: 69.49
+	Mm
		949937 TIF1A_MOUSE (1-1050): 0: 587: 92.23		CBX1_MOUSE (1-185): 2.21e-62: 193: 100.00
+	Hs
		170295 TIF1A_HUMAN (1-1050): 0: 590: 100.00		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Mm
		1143020 TIF1A_MOUSE (1-1050): 0: 587: 92.23		CBX5_MOUSE (1-183): 7.63e-60: 186: 57.98
+	Hs
		170481 TIF1A_HUMAN (1-1050): 0: 590: 100.00		CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07
+	Hs
		1027331 TRI33_HUMAN (53-1045): 1.19e-149: 477: 46.27		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		949915 TRI33_HUMAN (53-1045): 1.19e-149: 477: 46.27		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Hs
		1335793 TRI33_HUMAN (53-1045): 1.19e-149: 477: 46.27		CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07
+	Dm
		399034 Q9VDK5_DROME (9-1024): 2.35e-103: 352: 21.78		HP1_DROME (1-176): 7.89e-50: 161: 42.23
+	Dm
		68987 A8WHL4_DROME (9-1024): 1.51e-103: 352: 21.22		HP1_DROME (1-176): 7.89e-50: 161: 42.23
+	Hs
		1027278 TRI39_HUMAN (118-510): 4.03e-61: 219: 10.86		CBX3_HUMAN (1-177): 2.11e-63: 195: 69.49
+	Hs
		949891 TRI39_HUMAN (118-510): 4.03e-61: 219: 10.86		CBX1_HUMAN (1-185): 2.21e-62: 193: 100.00
+	Hs
		800532 TRI39_HUMAN (118-510): 4.03e-61: 219: 10.86		CBX5_HUMAN (1-183): 9.59e-60: 186: 57.45
+	Hs
		1335787 TRIM1_HUMAN (31-471): 1.64e-70: 252: 14.95		CBX8_HUMAN (12-88): 1.45e-24: 100: 35.07
+	Hs
		123298 CBP_HUMAN (386-1001): 1.83e-61: 232: 15.56		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Hs
		123174 RO52_HUMAN (114-485): 2.09e-64: 227: 12.67		CBX4_HUMAN (12-89): 1e-24: 101: 34.62
+	Hs
		203631 PML_HUMAN (23-555): 2.49e-55: 209: 18.15		SUV91_HUMAN (13-121): 4.22e-29: 112: 21.10
+	Hs
		316043 LIN41_HUMAN (66-430): 5.44e-55: 208: 18.29		CBX6_HUMAN (12-101): 1.25e-25: 103: 30.00
+	Hs
		123187 PML_HUMAN (23-555): 2.49e-55: 209: 18.15		CBX4_HUMAN (12-89): 1e-24: 101: 34.62