HitPredict - High confidence protein-protein interactions

Interactor 1: AXIN1 (O15169)
Axin-1 (Axis inhibition protein 1) (hAxin)
Gene: AXIN1

Interactor 2: AXIN2 (Q9Y2T1)
Axin-2 (Axin-like protein) (Axil) (Axis inhibition protein 2) (Conductin)
Gene: AXIN2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	20128690, 22682247
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	DIX~DIX, RGS~RGS
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane and 13 others more... GO:0008013 - beta-catenin binding GO:0009950 - dorsal/ventral axis specification GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0030877 - beta-catenin destruction complex GO:0031625 - ubiquitin protein ligase binding GO:0032436 - positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0048468 - cell development GO:0060070 - canonical Wnt signaling pathway GO:0060090 - molecular adaptor activity GO:0070411 - I-SMAD binding GO:0090090 - negative regulation of canonical Wnt signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	862
Hs

1	843

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Last updated: 15 Jul 2024