HitPredict

Interactor 1: TBXT (O15178)
T-box transcription factor T (Brachyury protein) (Protein T)
Gene: TBXT

Interactor 2: TLE5 (Q08117)
TLE family member 5 (Amino-terminal enhancer of split) (Amino enhancer of split) (Gp130-associated protein GAM) (Grg-5) (Groucho-related protein 5) (Protein ESP1) (Protein GRG) (TLE family member 5, transcriptional modulator)
Gene: TLE5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 197
+	Hs
		171019 TBXT_HUMAN (1-435): 1.23e-160: 461: 100.00		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		171017 TBXT_HUMAN (1-435): 1.23e-160: 461: 100.00		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		171018 TBXT_HUMAN (1-435): 1.23e-160: 461: 100.00		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980958 TBX20_HUMAN (26-345): 7.48e-105: 319: 36.23		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980667 TBX20_HUMAN (26-345): 7.48e-105: 319: 36.23		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		203427 TBX1_HUMAN (39-261): 6.11e-102: 311: 40.34		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		168131 TBX3_HUMAN (16-426): 3.57e-102: 321: 28.83		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980911 TBX20_HUMAN (26-345): 7.48e-105: 319: 36.23		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980935 TBR1_HUMAN (9-434): 6.17e-93: 296: 29.25		TLE4_HUMAN (2-191): 3.57e-112: 338: 68.59
+	Hs
		980617 TBR1_HUMAN (9-434): 6.17e-93: 296: 29.25		TLE1_HUMAN (2-197): 2.47e-111: 336: 64.50
+	Hs
		980849 TBX15_HUMAN (2-379): 1.12e-95: 301: 28.50		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		980761 TBR1_HUMAN (9-434): 6.17e-93: 296: 29.25		TLE3_HUMAN (2-197): 3.95e-105: 320: 61.50
+	Hs
		168132 TBX3_HUMAN (16-426): 3.57e-102: 321: 28.83		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		1132995 TBX20_HUMAN (26-345): 7.48e-105: 319: 36.23		Q5T3G3_HUMAN (2-197): 1.07e-99: 290: 61.43
+	Hs
		1127614 TBX20_HUMAN (26-345): 7.48e-105: 319: 36.23		Q5JSZ1_HUMAN (2-192): 7.66e-95: 277: 63.11
+	Hs
		327890 TBX6_HUMAN (25-343): 4.26e-98: 302: 33.64		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Hs
		993440 TBR1_HUMAN (9-434): 6.17e-93: 296: 29.25		TLE5_HUMAN (1-197): 3.1e-101: 292: 100.00
+	Dm
		558401 Q9VMR2_DROME (42-274): 8.68e-89: 282: 38.65		GROU_DROME (2-163): 3.54e-59: 198: 54.44
+	Ce
		137679 TBX2_CAEEL (26-386): 7.01e-101: 309: 28.96		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47
+	Ce
		137656 TBX1_CAEEL (42-221): 6.71e-98: 295: 49.73		UNC37_CAEEL (18-160): 8.43e-43: 153: 28.47