HitPredict

Interactor 1: RGL2 (O15211)
Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)
Gene: RGL2

Interactor 2: RAP1B (P61224)
Ras-related protein Rap-1b (EC 3.6.5.2) (GTP-binding protein smg p21B)
Gene: RAP1B

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	8939933, 21988832
Identification Methods	two hybrid, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 777 Hs			1 184
+	Hs
		171545 RGL2_HUMAN (11-777): 0: 804: 100.00		RAC1_HUMAN (1-184): 1.05e-68: 209: 27.55
+	Hs
		171532 RGL2_HUMAN (11-777): 0: 804: 100.00		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49
+	Hs
		171533 RGL2_HUMAN (11-777): 0: 804: 100.00		RASK_HUMAN (1-167): 6.26e-55: 174: 57.49
+	Hs
		171535 RGL2_HUMAN (11-777): 0: 804: 100.00		RALA_HUMAN (4-168): 2.03e-54: 173: 51.52
+	Hs
		171531 RGL2_HUMAN (11-777): 0: 804: 100.00		RASN_HUMAN (1-167): 5.03e-54: 171: 56.89
+	Mm
		699619 RGL2_MOUSE (11-777): 0: 800: 89.58		RASK_MOUSE (1-167): 1.17e-54: 173: 57.49
+	Mm
		440302 RGL2_MOUSE (11-777): 0: 800: 89.58		RASN_MOUSE (1-167): 4.36e-54: 171: 56.89
+	Hs
		897964 RGL1_HUMAN (49-760): 0: 581: 32.27		RAP1B_HUMAN (1-184): 3.62e-74: 222: 100.00
+	Hs
		919681 RGL1_HUMAN (49-760): 0: 581: 32.27		RAP1A_HUMAN (1-184): 2.59e-69: 210: 95.11
+	Hs
		486052 RGL1_HUMAN (49-760): 0: 581: 32.27		RAP2A_HUMAN (1-166): 6.9e-61: 188: 65.66
+	Hs
		1273185 RGL1_HUMAN (49-760): 0: 581: 32.27		RIT1_HUMAN (2-180): 7.98e-57: 179: 49.16
+	Hs
		349692 RGL1_HUMAN (49-760): 0: 581: 32.27		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49
+	Hs
		348971 RGL1_HUMAN (49-760): 0: 581: 32.27		RASN_HUMAN (1-167): 5.03e-54: 171: 56.89
+	Mm
		936775 RGL3_MOUSE (43-745): 0: 553: 34.53		RIT1_MOUSE (2-168): 1.06e-56: 179: 50.30
+	Mm
		1113379 RGL3_MOUSE (43-745): 0: 553: 34.53		RASH_MOUSE (1-167): 1.22e-55: 175: 57.49
+	Hs
		1109718 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RIT1_HUMAN (2-180): 7.98e-57: 179: 49.16
+	Hs
		349360 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49
+	Hs
		1109722 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RIT2_HUMAN (2-178): 1.4e-54: 174: 46.89
+	Hs
		348697 RGL3_HUMAN (43-745): 9.01e-177: 526: 35.11		RASN_HUMAN (1-167): 5.03e-54: 171: 56.89
+	Hs
		349455 GRP3_HUMAN (93-768): 3.48e-171: 511: 18.91		RASH_HUMAN (1-167): 1.22e-55: 175: 57.49