HitPredict

Interactor 1: RGL2 (O15211)
Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) (RalGDS-like factor) (Ras-associated protein RAB2L)
Gene: RGL2

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	1.00	0.656

Property	Details
Experiments	8939933
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 777 Hs			1 192
+	Hs
		925226 SOS1_HUMAN (23-694): 7.6e-152: 479: 20.25		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Mm
		1207971 Q8C5V7_MOUSE (2-526): 1.89e-115: 365: 22.92		RHOQ_MOUSE (4-187): 8.33e-85: 250: 64.13
+	Mm
		650205 RGRF1_MOUSE (6-516): 1.21e-116: 383: 21.09		RHOA_MOUSE (5-192): 1.43e-77: 231: 57.98
+	Hs
		156397 RGRF2_HUMAN (152-513): 5.26e-94: 321: 23.43		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		925267 RPGF1_HUMAN (11-526): 5.22e-95: 321: 21.91		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		892362 RPGF1_HUMAN (11-526): 5.22e-95: 321: 21.91		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		950984 RPGF1_HUMAN (11-526): 5.22e-95: 321: 21.91		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		156394 RGRF2_HUMAN (152-513): 5.26e-94: 321: 23.43		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		156395 RGRF2_HUMAN (152-513): 5.26e-94: 321: 23.43		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		951052 RGPS1_HUMAN (200-622): 1.99e-74: 254: 22.94		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		893950 GNDS_HUMAN (30-236): 4.58e-30: 129: 20.75		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31