HitPredict

Interactor 1: PFD6 (O15212)
Prefoldin subunit 6 (Protein Ke2)
Gene: PFDN6

Interactor 2: RMP (O94763)
Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein)
Gene: URI1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	27780869, 23667685, 31738558, 24981860, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Prefoldin~Prefoldin_2
Common GO terms	GO:0005737 - cytoplasm GO:0050821 - protein stabilization GO:0101031 - protein folding chaperone complex GO:1990062 - RPAP3/R2TP/prefoldin-like complex
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 129 Hs			1 535
+	Dm
		1363346 PFD6_DROME (5-122): 8.55e-31: 108: 47.46		PFD5_DROME (12-134): 4.41e-36: 133: 21.60
+	Hs
		171667 PFD6_HUMAN (1-119): 1.05e-29: 105: 100.00		PFD5_HUMAN (17-136): 2.31e-15: 75.3: 18.18
+	Sc
		854670 PFD6_YEAST (9-111): 3.72e-24: 91: 44.66		PFD5_YEAST (16-136): 7.82e-13: 68.3: 14.63
+	Ce
		854711 PFD6_CAEEL (8-115): 7.15e-24: 90.6: 42.59		PFD5_CAEEL (20-151): 8.16e-09: 56.4: 15.04
+	Sp
		145649 PFD6_SCHPO (9-105): 2.63e-20: 81.3: 37.11		PFD5_SCHPO (19-150): 7.2e-10: 59.5: 13.33