HitPredict

Interactor 1: GP182 (O15218)
G-protein coupled receptor 182
Gene: GPR182

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	7tm_1~Arrestin_C, 7tm_1~Arrestin_N
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 404 Hs			1 409
+	Hs
		674827 AGTR1_HUMAN (30-373): 1.61e-76: 242: 24.50		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		626815 ACKR3_HUMAN (20-368): 1.96e-86: 268: 29.53		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		626614 AGTRA_RAT (30-373): 4.43e-77: 244: 24.50		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		685822 OPRD_HUMAN (9-376): 2.45e-74: 237: 21.43		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		428933 ADRB2_HUMAN (23-399): 3.66e-72: 233: 15.70		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Hs
		685813 APJ_HUMAN (34-397): 3.04e-72: 232: 23.48		ARRB2_HUMAN (1-409): 0: 688: 100.00
+	Rn
		663954 Q8VBU7_RAT (23-360): 6.63e-72: 232: 16.80		ARRB2_RAT (1-409): 0: 682: 95.85
+	Hs
		674834 AGTR1_HUMAN (30-373): 1.61e-76: 242: 24.50		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Rn
		626613 AGTRA_RAT (30-373): 4.43e-77: 244: 24.50		ARRB1_RAT (1-399): 0: 654: 76.90
+	Hs
		781016 OPRD_HUMAN (9-376): 2.45e-74: 237: 21.43		ARRB1_HUMAN (1-407): 0: 661: 76.15
+	Mm
		669680 AGTRA_MOUSE (30-375): 3.07e-77: 244: 24.36		ARRB1_MOUSE (1-399): 0: 652: 76.90
+	Hs
		827128 CCR5_HUMAN (29-366): 7.27e-71: 228: 24.71		ARRB1_HUMAN (1-407): 0: 661: 76.15