HitPredict

Interactor 1: CASC3 (O15234)
Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)
Gene: CASC3

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	25640309, 29509190
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0019899 - enzyme binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 703 Hs			1 530
+	Hs
		172810 CASC3_HUMAN (1-703): 3.04e-79: 269: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		1056909 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		554348 MUC1_HUMAN (2-702): 4.1e-33: 139: 10.47		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369607 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368927 MUC1_HUMAN (2-702): 4.1e-33: 139: 10.47		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		302306 SC31A_HUMAN (343-634): 4.46e-17: 87.9: 13.16		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1243831 KMT2C_HUMAN (265-696): 9.73e-14: 77.5: 13.27		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1270066 PCLO_HUMAN (3-586): 4.63e-12: 72.2: 8.94		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269843 YM012_HUMAN (377-702): 4.21e-12: 71.4: 12.61		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1262687 ATX2L_HUMAN (106-703): 3.11e-11: 69.1: 10.52		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		370040 KMT2C_HUMAN (265-696): 9.73e-14: 77.5: 13.27		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370092 ATX2L_HUMAN (106-703): 3.11e-11: 69.1: 10.52		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		782595 KMT2C_HUMAN (265-696): 9.73e-14: 77.5: 13.27		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Mm
		101828 F8WI37_MOUSE (131-702): 6.38e-13: 74.8: 12.74		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Mm
		1142676 KMT2C_MOUSE (131-702): 6.27e-13: 74.8: 12.74		ERR2_MOUSE (69-499): 5.26e-107: 328: 31.11
+	Hs
		782578 SRCAP_HUMAN (73-702): 2.54e-11: 69.5: 10.32		HNF4A_HUMAN (94-502): 1.21e-107: 331: 23.30
+	Hs
		487431 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487832 ZMIZ1_HUMAN (280-695): 1.38e-28: 124: 14.06		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487596 KMT2C_HUMAN (265-696): 9.73e-14: 77.5: 13.27		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		487538 SRCAP_HUMAN (73-702): 2.54e-11: 69.5: 10.32		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59