HitPredict

Interactor 1: CASC3 (O15234)
Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz)
Gene: CASC3

Interactor 2: MED12 (Q93074)
Mediator of RNA polymerase II transcription subunit 12 (Activator-recruited cofactor 240 kDa component) (ARC240) (CAG repeat protein 45) (Mediator complex subunit 12) (OPA-containing protein) (Thyroid hormone receptor-associated protein complex 230 kDa component) (Trap230) (Trinucleotide repeat-containing gene 11 protein)
Gene: MED12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 703 Hs			1 2177
+	Hs
		1056918 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		MED12_HUMAN (1-2177): 0: 2488: 100.00
+	Hs
		172897 CASC3_HUMAN (1-703): 3.04e-79: 269: 100.00		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		1056974 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		WDR33_HUMAN (1594-2167): 1.1e-24: 115: 8.81
+	Hs
		1056910 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		1056953 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		1056898 MDC1_HUMAN (26-703): 5.64e-39: 157: 9.51		ARI1B_HUMAN (1839-2172): 5.1e-10: 67.3: 14.20
+	Hs
		1137775 OBSCN_HUMAN (253-702): 8.6e-09: 61.4: 9.73		DIDO1_HUMAN (1479-2099): 1.5e-18: 95.4: 10.74
+	Dm
		113976 M9PB30_DROME (4-690): 3.38e-14: 79.1: 8.88		M9PB30_DROME (1590-2174): 5.73e-10: 67.3: 7.06
+	Hs
		1057773 KMT2C_HUMAN (265-696): 9.73e-14: 77.5: 13.27		NCOA6_HUMAN (1716-2173): 1.71e-09: 65.7: 11.91
+	Mm
		1207212 KMT2C_MOUSE (131-702): 6.27e-13: 74.8: 12.74		NCOA6_MOUSE (1782-2166): 9.03e-10: 66.5: 13.89
+	Hs
		1170076 SRCAP_HUMAN (73-702): 2.54e-11: 69.5: 10.32		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		1262706 ATX2L_HUMAN (106-703): 3.11e-11: 69.1: 10.52		ATX2_HUMAN (1645-2176): 2.64e-11: 71.5: 9.32
+	Hs
		1172508 Q6ZTM8_HUMAN (120-598): 6.99e-11: 67.2: 8.55		CBP_HUMAN (1582-2176): 2.69e-11: 71.5: 13.45
+	Hs
		302269 SC24C_HUMAN (244-582): 2.22e-10: 66.4: 11.08		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Mm
		99853 F8WI37_MOUSE (131-702): 6.38e-13: 74.8: 12.74		F6M2J9_MOUSE (1841-2175): 8.77e-09: 63: 13.27
+	Hs
		1244276 ATX2L_HUMAN (106-703): 3.11e-11: 69.1: 10.52		ARI1B_HUMAN (1839-2172): 5.1e-10: 67.3: 14.20
+	Hs
		297843 SC24D_HUMAN (468-701): 2.35e-09: 62.9: 15.35		SC31A_HUMAN (1897-2176): 1.29e-11: 72.3: 11.54
+	Mm
		1351630 PCLO_MOUSE (2-694): 3.44e-10: 66: 9.07		PCLO_MOUSE (1546-2153): 1.3e-09: 66.1: 10.38