HitPredict

Interactor 1: MK13 (O15264)
Mitogen-activated protein kinase 13 (MAP kinase 13) (MAPK 13) (EC 2.7.11.24) (Mitogen-activated protein kinase p38 delta) (MAP kinase p38 delta) (Stress-activated protein kinase 4)
Gene: MAPK13

Interactor 2: STAT3 (P40763)
Signal transducer and activator of transcription 3 (Acute-phase response factor)
Gene: STAT3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	32852592
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0032755 - positive regulation of interleukin-6 production
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 365 Hs			1 770
+	Hs
		647492 MK03_HUMAN (12-354): 1.25e-144: 415: 43.43		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		658824 MK01_HUMAN (12-355): 3.63e-144: 414: 42.74		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Mm
		786542 MK03_MOUSE (15-354): 1.42e-143: 413: 43.23		STAT3_MOUSE (1-770): 0: 1049: 99.87
+	Hs
		776599 MK08_HUMAN (5-349): 1.76e-109: 328: 46.81		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		776600 MK09_HUMAN (9-349): 2.13e-109: 328: 47.19		STAT3_HUMAN (1-770): 0: 1048: 100.00
+	Hs
		658828 MK01_HUMAN (12-355): 3.63e-144: 414: 42.74		STAT1_HUMAN (1-749): 0: 929: 51.52
+	Mm
		926434 MK01_MOUSE (12-355): 3.04e-144: 414: 42.74		Q99K94_MOUSE (1-715): 0: 909: 53.62
+	Hs
		658829 MK01_HUMAN (12-355): 3.63e-144: 414: 42.74		STA5A_HUMAN (1-734): 0: 745: 30.42