HitPredict

Interactor 1: TRI18 (O15344)
E3 ubiquitin-protein ligase Midline-1 (EC 2.3.2.27) (Midin) (Putative transcription factor XPRF) (RING finger protein 59) (RING finger protein Midline-1) (RING-type E3 ubiquitin transferase Midline-1) (Tripartite motif-containing protein 18)
Gene: MID1

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29509190
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hormone_recep~fn3
Common GO terms	GO:0008270 - zinc ion binding GO:0019899 - enzyme binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 667 Hs			1 530
+	Hs
		659746 TRIM1_HUMAN (1-665): 4.96e-164: 490: 72.81		RXRB_HUMAN (96-498): 2.03e-108: 335: 27.05
+	Hs
		1052721 TRI25_HUMAN (4-656): 9.25e-108: 341: 22.80		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369597 TRI25_HUMAN (4-656): 9.25e-108: 341: 22.80		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487968 TRI25_HUMAN (4-656): 9.25e-108: 341: 22.80		RARA_HUMAN (52-505): 3.54e-105: 324: 23.74
+	Hs
		818879 TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39		RXRG_HUMAN (13-499): 1.71e-119: 361: 22.76
+	Hs
		370380 TRIM8_HUMAN (4-405): 5.33e-72: 244: 20.10		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		659723 TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39		RXRB_HUMAN (96-498): 2.03e-108: 335: 27.05
+	Hs
		377417 TRI67_HUMAN (54-660): 7.29e-91: 301: 24.39		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		536957 TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		377659 TRIM8_HUMAN (4-405): 5.33e-72: 244: 20.10		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		734717 TRI23_HUMAN (8-252): 7.45e-19: 92.4: 25.88		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368914 TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370187 TRI11_HUMAN (3-249): 9.34e-19: 91.7: 19.03		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		487428 TRI25_HUMAN (4-656): 9.25e-108: 341: 22.80		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59
+	Hs
		536736 TRI27_HUMAN (90-433): 1.46e-30: 128: 14.08		RXRB_HUMAN (96-498): 2.03e-108: 335: 27.05
+	Hs
		242811 TRI13_HUMAN (1-97): 1.22e-14: 78.2: 40.21		NR4A1_HUMAN (7-501): 3.18e-101: 318: 25.30
+	Hs
		487517 TRI68_HUMAN (108-371): 1.05e-14: 79: 15.39		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59