Interactor 1: P73 (O15350)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: TP73

Interactor 2: P73 (O15350)
Tumor protein p73 (p53-like transcription factor) (p53-related protein)
Gene: TP73

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.87 1.00 0.933

The method score is based on:

Property Details
Experiments 9802988, 10961991, 19815500, 22474346, 22340593
Identification Methods two hybrid, x-ray crystallography, mass spectrometry studies of complexes, cosedimentation in solution, cross-linking study, anti tag coimmunoprecipitation, comigration in non denaturing gel electrophoresis
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains P53~P53, P53~P53_tetramer, P53_tetramer~P53_tetramer, SAM_2~SAM_2
Common GO terms GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 - transcription corepressor binding
and 36 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 636
Hs

1 636
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Dr
+ Dr
+ Mm
+ Hs
+ Dm

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Last updated: 15 Jul 2024